糖肾康方对db/db小鼠糖脂代谢及肾脏组织病理的影响
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R285.5

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国家自然科学基金项目(81460699);甘肃省自然科学基金项目(1308RJZA202);2015国家中医临床研究基地建设专项项目(JDZX2015240)


Tang Shen Kang Prescription Has Effect on Glucose and Lipid Metabolism and Pathology of Kidney Tissues in db/db Mice
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    摘要:

    目的:观察糖肾康方(TSK)对db/db小鼠血糖、血脂、24 h尿白蛋白及对肾脏组织形态的影响。方法:12周龄SPF级雄性db/db小鼠,随机分为空白组、模型组、TSK给药组(TSK高、中、低剂量组),连续喂养12周,记录体质量、血脂、血糖及24 h尿白蛋白水平,观察肾脏病理改变。结果:与空白组比较,模型组小鼠体质量增加,血糖升高,24 h尿白蛋白维持在高水平(P<0.05),肾小球系膜基质增生;与模型组比较,TSK给药组db/db小鼠体质量降低,中、高剂量组随治疗时间的延长,可明显降低血糖、血脂及24 h尿白蛋白水平(P<0.05),改善肾组织病理改变。结论:TSK对db/db小鼠肾脏具有保护作用,其机制与降低血脂、血糖,改善糖毒性和脂毒性有关,同时可以改善肾小球系膜增殖。

    Abstract:

    Objective:To observe the effect of Tang Shen Kang prescription(TSK)on the blood glucose,blood lipid,24h urinary protein and morphology of kidney tissues in db/db mice.Methods:Twelve-week-old male db/db mice at SPF level were randomly divided into the blank group,the model group(the db/db group),the TSK groups of high,middle and low dose.They were fed for 12 weeks.Recorded the levels of body mass,blood lipid,blood glucose and 24h urinary protein,and observed the pathological changes of kidney.Results:Compared with the blank group,in the model group,the levels of body mass and the blood glucose were increased,and the level of 24h urinary protein maintained high(P<0.05);hyperplasia of glomerular mesangial matrix occurred.Compared with the model group,the body weight of db/db mice in the TSK groups were decreased;as the prolongation of treatment time,the levels of blood glucose,blood lipid and 24h urinary protein were significantly decreased in the TSK groups of high and middle dose(P<0.05);pathological changes of kidney tissues were improved.Conclusion:TSK can protect the kidney of db/db mice.Its mechanism is related to the reduction of blood lipid and blood glucose and the improvement of glucotoxicity and lipid toxicity,which can improve the proliferation of glomerular mesangium.

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张东鹏,张定华,史晓伟,刘怡,裴文丽.糖肾康方对db/db小鼠糖脂代谢及肾脏组织病理的影响[J].新中医,2018,50(12):1-4

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  • 在线发布日期: 2018-12-09
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