Objective：To observe the effect of different prescriptions of AiKang tablets in the models of experimental animal nephritis.Methods：Divided SD rats randomly into the sham operation group，the model group，the amoxicillin group，the high-dose group of the original prescription，the small-dose group of the original prescription，the high-dose group lacking Kushen，and the small-dose group lacking Kushen，10 rats in each group.Made acute pyelonephritis models by means of intravesical injection of Escherichia coli(E.coli)and cultured bladder puncture drainage after treatment.Divided Japanese white rabbits randomly into the normal group，the model group，the tripterygium tablets group，the high-dose group of the original prescription，the small-dose group of the original prescription，the high-dose group lacking Kushen，and the small-dose group lacking Kushen，6 rabbits in each group.Prepared models of acute serum sickness nephritis by injecting with bovine serum albumin，and detected circulating immune complexes(CIC)，creatinine(Cr)and blood urea nitrogen(BUN).Results：In the models of infectious pyelonephritis，compared with the sham operation group， all the bladder puncture drainage in the model group had bacterial growth，suggesting successful modeling；compared with the model group，the proportions of rats of positive culture of escherichia coli in the amoxicillin group，the small-dose group of the original prescription and the small-dose group lacking Kushen were all significantly decreased(P＜0.05).In the models of acute serum sickness nephritis，compared with the model group，the content of serum CIC in all drug-administered groups was evidently reduced(P＜0.05，P＜0.01).Conclusion：The small-dose groups of Aikang tablets in the two different prescriptions have significant effects for infectious rat models with escherichia coli；in the models of acute serum sickness nephritis，the two different prescriptions show effectiveness in reducing CIC.In view of the two disease models，the original prescription is more effective.