Objective：To study the anti-hepatic fibrosis effect of matrine combined with amygdalin.Methods：Forty male C57BL/6 mice were divided into five groups，included five in the normal group，five in the model group，ten in the matrine group，ten in the mandelic group and ten in the combined treatment group.Established the model of mice with hepatic fibrosis by induction of carbon tetrachloride，and determined the degree of hepatic fibrosis and the staining area of fibrosis via Sirius red staining；evaluated the concentration of hydroxyproline and detected the status of fibrous deposition by means of kits；detected the changes of contents of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in serum.Results：Comparing with the normal group，the body mass of mice in the model group was significantly decreased，the levels of ALT and AST in serum were increased，and hepatic fibrosis was evident，differences being significant(P＜0.01).Comparing with the model group，the average body mass of mice in the matrine group，the amygdalin group and the combination group was increased respectively，but there was significant difference being found only in the combination group(P＜0.01).The Ishak scores of hepatic fibrosis in liver tissue of mice，the area of Sirius red collagen staining，concentration of hydroxyproline and levels of ALT and AST in serum were evidently decreased in all groups，among which the effect in the combination group was the most evident，differences being significant(P＜0.05，P＜0.01).Conclusion：The combined application of matrine and amygdalin has significant anti-hepatic fibrosis effect，and its therapeutic effect is evidently better than the simple application of matrine and amygdalin.