Objective：To detect intima-media thickness(IMT)in carotid，endothelium-dependent dilation function(FMD)，and the content of nitric oxide(NO)in serum and vascular endothelin-1(ET-1)in patients with acute cerebral infarction before and after they were given Zhali Nusi prescripion，and observed the effect of Zhali Nusi prescripion on the vascular endothelial function of acute cerebral infarction and elaborated its mechanism.Methods：Selected 120 patients with atherosclerotic cerebral infarction and randomly divided them into two groups，60 cases in each group.The two groups were routinely given basic treatment of internal medicine.The drug group additionally received Zhali Nusi prescripion，one dose per day.Evaluated the degree of neurologic function deficits by using national institutes of health stroke scale(NIHSS)before and 12 weeks after administration of drugs； detected IMT by applying color ultrasonic diagnostic apparatus； calculated FMD after reactive hyperemia；determined the level of NO in serum by nitrate reductase assay；measured the level of ET-1 in plasma by radioimmunoassay.Results：Compared with that before treatment，the NIHSS scores of the two groups after treatment were significantly decreased，difference being significant(P＜0.01)；compared with that in the control group，the NIHSS scores of patients in the drug group were evidently decreased，difference being significant(P＜0.05).Compared with those before treatment，the levels of NO and FMD in the two groups were obviously increased after treatment，and the levels of ET-1 and IMT were clearly decreased，differences being significant(P＜0.05，P＜0.01).Compared with those in the control group after treatment，the levels of NO and FMD in the drug group were significantly increased，and the levels of ET-1 and IMT were markedly decreased，difference being significant(P＜0.05，P＜0.01).Conclusion：The application of Zhali Nusi prescripion has definite effect in treating cerebral infarction.Its mechanism may be related to the action of improving vascular endothelial function.