Objective：To observe the clinical effect of Renshen Bufei drink combined with western medicine therapy for chronic obstructive pulmonary disease(COPD)with emphysema phenotype.Methods：Divided 78 cases of patients into two groups randomly，39 cases in each group.The control group received the inhalation of ipratropium bromide aerosol and the oral administration of theophylline sustained release tablets，while the treatment group additionally received Renshen Bufei drink.The treatment for both groups lasted for 16 weeks.Before and after treatment，scored COPD assessment test(CAT)，St.George’s respiratory questionnaire(SGRQ)and syndrome of yin-qi deficiency in lung and kidney，conducted pulmonary function test，and evaluated pulmonary function according to the severity of airflow limitation.Results：After rank sun test，the clinical effect in the treatment group was better than that in the control group，difference being significant(P＜0.05).After treatment，the grading of pulmonary function indicated that the severity of airflow limitation in the treatment group was lower than that in the control group，difference being significant(P＜0.05).After treatment，forced expiratory volume in one second(FEV1)and FEV1%in both groups were higher than those before treatment(P＜0.05)； FEV1and FEV1%in the treatment group were respectively higher than those in the control group(P＜0.05).After treatment，the total scores and scores of SGRQ from three dimensions of respiratory symptoms，activity ability and disease influence in both groups were decreased(P＜0.01)；the total score and scores from each dimension in the treatment group were all lower than those in the control group(P＜0.01).Conclusion：The additional application of Renshen Bufei drink based on western medicine therapy can alleviate clinical symptoms and the severity of airflow limitation in COPD with emphysema phenotype，improve pulmonary function and elevate the quality of life of patients，of which the comprehensive clinical effect is significant.