金水六君煎合生脉散加减治疗慢性阻塞性肺疾病稳定期临床观察
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R563.9

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浙江省中医药防治重大疾病攻关计划项目 (2012ZGG002)


Clinical Observation on Modified Jinshui Liujun Jian Combined with Shengmai Powder for COPD in Stable Phase
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    摘要:

    目的:观察金水六君煎合生脉散加减对慢性阻塞性肺疾病(COPD)稳定期患者的临床疗效。方法:将60例符合纳入标准的COPD稳定期患者随机分为2组,每组30例,对照组予西药治疗,观察组采用金水六君煎合生脉散加减联合西药治疗,治疗6月后,评价2组中医症状积分、肺功能、慢性阻塞性肺疾病评估测试(CAT)评分及急性加重次数。结果:2组治疗3月后、治疗6月后中医症状积分分别与本组治疗前比较,均降低,差异均有统计学意义(P<0.05)。观察组治疗3月后、治疗6月后中医症状积分均低于对照组,差异均有统计学意义(P<0.05)。治疗6月后,2组第1秒用力呼气容积(FEV1),第1秒用力呼气容积占用力肺活量百分比(FEV1/FVC),FEV1占预计值百分比(FEV1%) 分别与治疗前比较,差异均无统计学意义(P>0.05)。2组治疗3月后、治疗6月后CAT评分分别与本组治疗前评分比较,均明显降低,差异均有统计学意义(P<0.05)。2组治疗3月间、治疗3~6月间,急性加重次数均较治疗前3月间减少,差异均有统计学意义(P<0.05)。观察组在治疗3~6月间,急性加重次数少于同期对照组,差异有统计学意义(P<0.05)。结论:金水六君煎合生脉散加减治疗可以改善COPD稳定期患者的中医症状和生活质量,减少急性加重次数。

    Abstract:

    Objective:To observe the clinical effect of modified Jinshui Liujun jian combined with Shengmai powder for patients with chronic obstructive pulmonary disease(COPD)in stable phase.Methods:Randomly divided 60 cases of patients with COPD in stable phase who met the inclusion criteria into two groups,30 cases in each group.The control group was treated with western medicine,while the observation group was given modified Jinshui Liujun jian combined with Shengmai powder and western medicine.After six months of treatment,evaluated the scores of Chinese medicine symptoms,lung function, COPD Assessment Test(CAT)and the times of acute exacerbation in the two groups.Results:The scores of Chinese medicine symptoms after the third and the sixth month of treatment in the two groups were decreased when compared with those before treatment respectively,differences being significant(P<0.05).The scores of Chinese medicine symptoms after the third and the sixth month of treatment in the observation group were lower than those in the control group,differences being significant(P<0.05).After six months of treatment,there was no significant difference being found in the comparisons of the forced expiratory volume in one second(FEV1),the percentage of FEV1to forced vital capacity(FEV1/FVC),and the percent predicted(FEV1%)between the two groups when compared with those before treatment(P>0.05).The CAT scores after the third and the sixth month of treatment in the two groups were significantly decreased when compared with those before treatment,differences being significant(P<0.05).The two groups had fewer times of acute exacerbation during the first three-month treatment and during the third to the sixth month of treatment than during the three months before treatment,differences being significant(P< 0.05).The observation group had fewer timesof acute exacerbation during the third to the sixth month of treatment than the control group at the same period,the difference being significant(P<0.05).Conclusion:The therapy of modified Jinshui Liujun jian combined with Shengmai powder can improve the Chinese medicine symptoms and quality of life for patients with COPD in stable phase,and reduce the times of acute exacerbation.

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官凯悦,晏露宁,程岭,俞正秋,蔡宛如.金水六君煎合生脉散加减治疗慢性阻塞性肺疾病稳定期临床观察[J].新中医,2018,50(12):83-86

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  • 在线发布日期: 2018-12-09
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