Objective：To observe the clinical effect of compound Biejia Ruangan tablets combined with adefovir dipivoxil for chronic hepatitis B(CHB)with syndrome of static blood blocking collaterals and its effect on serum factors related to the liver function.Methods：Divided 88 cases of patients into two groups according to the random number table method，44 cases in each group.The control group was treated with adefovir dipivoxil tablets，while the observation group was additionally given compound Biejia Ruangan tablets for treatment based on the treatment of the control group.Both groups were treated for one year.Before and after treatment，recorded changes in HBV-DNA load，compared changes in serum factors related to the liver function including aspartate aminotransferase(AST)，alanine aminotransferase(ALT)，total bilirubin(TBil)，and gamma-glutamyltransferase(GGT)，and statistically analyzed the clinical effect and incidence of adverse reactions in the two groups.Results：After the 24thand 28thweeks of treatment，the HBV-DNA load in both groups was decreased when compared with that before treatment(P＜0.05).The decreased of HBV-DNA load in the observation group was more obvious than that in control group at the same period(P＜0.05).After treatment，levels of AST，ALT，TBil and GGT in the two groups were decreased when compared with those before treatment(P＜0.05)，and the decrease of levels of the above indexes in the observation group was more obvious than that in control group(P＜0.05).The total effective rate was 86.4%in the observation group and 63.6%in the control group，the difference being significant(P＜0.05).The incidence of adverse reactions was 4.5% in the observation group and 13.6% in the control group，the difference being significant(P＜0.05).Conclusion：The therapy of compound Biejia Ruangan tablets combined with adefovir dipivoxil tablets for CHB with syndrome of static blood blocking collaterals can reduce virus replication，whose therapeutic effect is superior to that of simple western medicine with better safety.