Objective：To evaluate the clinical effect of liver-smoothing and spleen-invigorating method intervening Hashimoto's thyroiditis.Methods：Divided 76 cases of patients into two groups randomly，38 cases in each group.The control group received the oral administration of Euthyrox，while the research group additionally received liver-smoothing and spleen-invigorating prescription.The treatment for both groups lasted for 3 months.Observed the levels of thyroglobulin antibody(TGAb)，thyroid microsomal antibody(TMAb)，thyroid stimulating hormone(TSH)，low density lipoprotein cholesterol(LDL-C)， high density lipoprotein cholesterol(HDL-C)and serum total cholesterol(TC)， recorded the degree of thyroid enlargement，and valuated the clinical effect and recurrence rate.Results：After treatment，the levels of TSH，TMAb and TGAb in both groups were lower than those before treatment(P＜0.05)，and the levels of TMAb and TGAb in the research group were lower than those in the control group(P＜0.05).The levels of TC and LDL-C in both groups were decreased，and the levels of TC and LDL-C in the research group were lower than those in the control group(P＜0.05)；the level of HDL-C in both groups was increased respectively，and the level of HDL-C in the research group was lower than that in the control group(P＜0.05).After treatment for 3 months，the cure rate of thyroid enlargement was 47.37%(18/38)in the research group，being significantly higher than 18.42%(7/38)in the control group(P＜0.05).After drug withdrawal for half a year，the recurrence rate of subclinical hypothyroidism was 16.67%(3/18)in the research group，being significantly lower than 71.43%(5/7)in the control group(P＜0.05).Conclusion：Euthyrox combined with liver-smoothing and spleen-invigorating prescription helps to improve the thyroid function and the level of lipid in peripheral blood of patients with Hashimoto's thyroiditis of liver-depression and spleen-deficiency type，thus to enhance the clinical effect.