Objective：To observe the clinical effect of Xuefu Zhuyu tang for patients undergoing hemodialysis with restless legs syndrome(RLS).Methods：Divided 40 cases of patients undergoing persistent hemodialysis with RLS into two groups randomly.The two groups received routine treatment of hemodialysis and symptomatic treatment.The observation group additionally received Xuefu Zhuyu tang for treatment，while the control group additionally received oral administration of gabapentin.The treatment lasted for eight weeks.Evaluated the patients with international restless legs scale(IRLS)and detected the indexes of albumin，serum creatinine，urea nitrogen，serum uric acid，alkaline phosphatase，hemoglobin，transferrin saturation， potassium， calcium， phosphorusand intact parathyroid hormone of patientsbefore and after treatment.Results：After treatment，the levels of hemoglobin in the two groups were improved when compared with those before treatment(P＜0.01)，but no significant difference was found in the comparison of hemoglobin between the two groups(P＞0.05).The level of serum albumin in the observation group was improved when compared with that before treatment(P＜0.05)，but no significant difference was found in the comparison of serum albumin between the two groups(P＞0.05).After treatment，the level of serum potassium in the observation group was increased when compared with that before treatment(P＜0.05)，but no significant difference was found in the comparison of serum potassium between the two groups(P＞0.05).After treatment，RLS scores in the two groups were significantly decreased when compared with those before treatment(P＜0.01)，but no significant difference was found in the comparison of RLS scores between the two groups(P＞0.05).The above results proved that Xuefu Zhuyu tang can improve the clinical symptoms of patients and its curative effect is equivalent to that of gabapentin.Conclusion：The therapy of modified Xuefu Zhuyu tang can relieve the symptoms of patients，whose curative effect is equivalent to that of gabapentin.