Objective：To observe the clinical effect of modified Guizhi Fuling pills combined with mifepristone for hysteromyoma of blood stasis due to congealing cold type，and its effect on inflammatory factors in serum of patients.Methods：Divided 116 cases of patients into two groups randomly，58 cases in each group.The control group received mifepristone，while the observation group additionally received the oral administration of modified Guizhi Fuling pills.The course of treatment lasted for 3 months.Observed the changes of menstrual symptoms and clinical symptoms of patients in both groups before and after treatment，detected the contents of tumor necrosis factor- α(TNF-α)，interleukin-6(IL-6)，interleukin-8(IL-8)，luteinizing hormone(LH)，progesterone(P)，follicle stimulating hormone(FSH)and estradiol(E2)in serum.Results：After treatment，the incidence of such menstrual symptoms as premenstrual mammary swelling pain，menorrhagia，waist soreness，lower abdomen pain and blood clot in both groups was respectively lower than that before treatment(P＜0.05)；the incidence of each symptom above in the observation group was decreased more significantly than that in the control group(P＜0.05).After treatment，the incidence of such clinical symptoms as feverish palms，proctalgia，impetuosity and irascibility，intercourse pain，pollakiuria，dry mouth and hypodynamia in both groups was respectively lower than that before treatment(P＜ 0.05)；the incidence of such clinical symptoms as impetuosity and irascibility，dry mouth and hypodynamia in the observation group was decreased more significantly than that in the control group(P＜0.05).After treatment，the levels of TNF-α，IL-6，IL-8，LH，P，FSH and E2in serum of patients in both groups were lower than those before treatment(P＜0.05)；each index above in the observation group was improved more significantly than those in the control group(P＜0.05).Conclusion：Modified Guizhi Fuling pills combined with mifepristone can significantly improve the menstrual symptoms and clinical symptoms of patients with hysteromyoma of blood stasis due to congealing cold type，and ameliorate inflammatory factors in serum，of which the clinical effect is better than the simple application of western medicine.