大坤丹联合戊酸雌二醇片治疗薄型子宫内膜不孕症临床观察
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R711.6

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大连市科技计划项目 (2015E12SF131)


Clinical Observation of Dakundan Combined with Estradiol Valerate Tablets for Infertility due to Thin Endometrium
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    摘要:

    目的:观察大坤丹联合戊酸雌二醇片治疗薄型子宫内膜(EM)不孕症的临床疗效。方法:将72例薄型EM不孕症患者按随机数字表法分为观察组和对照组各36例,其中对照组1例未按治疗方案执行剔除。2组均予戊酸雌二醇片口服,观察组在此基础上加服大坤丹,2组均治疗3个月经周期。观察治疗前后中医证候评分、EM厚度、EM螺旋动脉收缩期峰值血流速度(PSV)与阻力指数(RI)的变化,对比2组临床疗效及妊娠率。结果:与治疗前相比,2组治疗后中医证候评分均降低(P<0.05),观察组中医证候评分比对照组降低更明显(P<0.05)。与治疗前比较,2组治疗后EM厚度均有所增大(P<0.05),观察组EM厚度大于对照组(P<0.05)。与治疗前比较,观察组治疗后EM螺旋动脉PSV增高,RI下降,差异均有统计学意义(P<0.05)。对照组治疗前后EM螺旋动脉PSV、RI均无明显变化(P>0.05)。观察组治疗总有效率88.9%,对照组治疗总有效率68.6%,2组比较,差异有统计学意义(P<0.05)。观察组妊娠率33.3%,对照组妊娠率11.4%,2组比较,差异有统计学意义(P<0.05)。结论:大坤丹联合戊酸雌二醇片治疗薄型EM不孕症临床疗效确切,可有效改善EM形态及局部血流状况,提高妊娠率。

    Abstract:

    Objective:To observe the clinical effect of Dakundan combined with estradiol valerate tablets for infertility due to thin endometrium(EM).Methods:Divided 72 cases of patients with infertility due to thin EM into the observation group and the control group randomly according to the random number table,36 cases in each group.One case of patient in the control group was not excluded according to the treatment plan.Both groups were given oral administration of estradiol valerate tablets,and the observation group was additionally given Dakundan.The treatment for both groups lasted for 3 menstrual cycles.Observed the changes of Chinese medicine syndrome scores,EM thickness,peak systolic blood flow velocity(PSV)of EM helicine artery and resistance index(RI)before and after treatment,and compared the clinical effect and pregnancy rate in the two groups.Results:Compared with that before treatment,the Chinese medicine syndrome scores of the two groups were decreased after treatment(P<0.05);the decrease of Chinese medicine syndrome scores in the observation group was significantly lower than that in the control group(P<0.05).Compared with that before treatment,the EM thickness in the two groups was increased after treatment(P<0.05);the EM thickness in the observation group was thicker than that in the control group(P<0.05).Compared with that before treatment,the PSV of the EM spiral artery in the observation group was increased and RI was decreased after treatment,differences being significant(P<0.05).There were no significant changes being found in comparisons of PSV and RI of the EM spiral arteries in the control group before and after treatment(P>0.05).The total effective rate was 88.9%in the observation group and 68.6%in the control group,compared the two groups,difference being significant(P<0.05).The pregnancy rate was 33.3%in the observation group and 11.4%in the control group,compared the two groups,difference being significant(P<0.05).Conclusion:The application of Dakundan combined with estradiol valerate tablets has significant curative effect in treating infertility due to thin EM.It can effectively improve EM morphology and local blood flow and promote pregnancy rate.

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王宝成,王丽昊,白长川.大坤丹联合戊酸雌二醇片治疗薄型子宫内膜不孕症临床观察[J].新中医,2018,50(12):153-156

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  • 在线发布日期: 2018-12-09
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