Objective：To observe the clinical effect of Niaotong Kake'naiqi tablets combined with levofloxacin for women with lower urinary tract infection.Methods：Divided 96 cases of women with acute lower urinary tract infection into two groups according to the random number table method，48 cases in each group.The western medicine group was treated with levofloxacin capsules，while the combination group was additionally given Niaotong Kake'naiqi tablets based on the treatment of the control group.The two groups received treatment for one week.Compared the clinical effect，elimination time of symptoms， urinary leukocyte and erythrocyte count， adverse drug reactions， and the recurrence rate of six months of follow-up in the two groups.Results：After treatment，the total effective rate was 93.75%in the combination group and 81.25%in the western medicine group，the difference being significant(P＜0.05).After treatment，the elimination time of clinical symptoms as frequent urination，urgent urination，painful urination，and gross hematuria in the combination group was shorter than that in the western medicine group，differences being significant(P＜0.05，P＜0.01).After treatment，compared the urinary leukocyte and erythrocyte count between the two groups with those before treatment，differences were significant(P＜0.05，P＜0.01).Compared the urinary leukocyte and erythrocyte count in the combination group with those in the western medicine group，differences being significant(P＜0.05).After following up for half a year，the recurrence rate in the combination group was lower than that in the western medicine group(P＜0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P＞0.05).Conclusion：The therapy of Niaotong Kake'naiqi tablets combined with levofloxacin has significant effect for women with lower urinary tract infection，which can obviously improve the clinical symptoms of patients，reduce recurrence rate but will not increase adverse reactions.