Objective：To observe the clinical effect of XiaoXuming tang combined with comprehensive rehabilitation treatment for severe hand-foot-and-mouth disease in the convalescence phase.Methods：Selected 64 children with hand-foot-and-mouth disease who met the inclusion criteria and randomly divided them into two groups，32 cases in each group.The control group was given symptomatic treatments such as acupuncture and moxibustionn，tuina，and nutritional nerves，while the observation group wasadditionally given modified Xiaoxuming tang based on clinical syndrome differentiation.Compared the clinical effect of gross motor， intelligence and language recovery， recovery time of consciousness and gross motor，and the total time of comprehensive rehabilitation treatment in the two groups.Results：The total clinical effective rate was 96.80%in the observation group and 81.25%in the control group，difference being significant(P＜0.05).It indicated that the total effective rate of gross motor，intelligence and language recovery in the observation group was significantly better than that in the control group.The recovery time of consciousness and gross motor and the total time of rehabilitation treatment in the observation group were clearly shorter than those in the control group，differences being significant(P＜0.05).Conclusion：The application of XiaoXuming tang combined with comprehensive rehabilitation treatment can promote the clinical effect of severe hand-foot-and-mouth disease in the convalescence phase，shorten the course of disease and improve the prognosis.