Objective：To observe the clinical effect of Qingre Lishi tang for oral lichen planus(OLP)of dampness-heat of spleen and stomach type.Methods：Divided 60 cases of patients with OLP of dampness-heat of spleen and stomach type into the control group and the observation group randomly，30 cases in each group.The control group received transfer factor oral solution for treatment，while the observation group received Qingre Lishi tang.After treatment，evaluated the clinical effect and observed the changes in relevant indexes before and after treatment in the two groups.Results：The total effective rate was 90.00%in the observation group，higher than that of 66.67%in the control group，the difference being significant(P＜0.05).Before treatment，no significant difference was found in the comparisons of the scores of symptoms and signs between the two groups(P＞0.05).After treatment，the scores of symptoms and signs in the two groups were decreased when compared with those before treatment，differences being significant(P＜0.05).The scores of symptoms and signs in the observation group were lower than those in the control group，the difference being significant(P＜0.05).Before treatment，no significant difference was found in the comparisons of the levels of IgA and IgG between the two groups(P＞0.05).After treatment，compared with the levels of IgA in the two groups before treatment，there was no significance in the difference(P＞0.05).Levels of IgG in the two groups were decreased when compared with those before treatment，differences being significant(P＜0.05).Level of IgG in the observation group was lower than that in the control group，the difference being significant(P＜0.05).Conclusion：Qingre Lishi tang for OLP of dampness-heat of spleen and stomach type can effectively improve the clinical symptoms and immune indexes of patients.