Objective：To observe the clinical effect of Guipi tang for mild-to-moderate anemia related to gastric cancer.Methods：Eighty cases of patients with gastric cancer anemia were included in the study and were divided into two groups randomly，40 cases in each group.The treatment group received decoction which mainly included Guipi tang and was modified by the treatment based on syndrome differentiation.The control group was treated with ferrous succinate tablets orally and was additionally treated with folic acid tablets and vitamin B12tablets according to complications.Observed the changes in levels of hemoglobin and erythrocyte，T lymphocyte subsets，the number of natural killer(NK)cell and the score of karnofsly's performance status(KPS).The observation lasted for two months.Results：After treatment of one month，the level of hemoglobin in the treatment group was increased when compared with that before treatment，the difference being significant(P＜0.05).After treatment of two months，levels of hemoglobin and erythrocyte in the two groups were increased when compared with those before treatment，differences being significant(P＜0.05).Compared with those in the control group during the same period，levels of hemoglobin and erythrocyte in the treatment group were increased，differences being significant(P＜0.05).After treatment of two months，values of CD4+，CD4+/CD8+and CD16+56+in the treatment group were increased when compared with those before treatment，differences being significant(P＜0.05).After treatment of two months，compared with the values of CD4+，CD4+/CD8+and CD16+56+between the two groups respectively，differences were significant(P＜0.05).After treatment of one month and two months，compared with KPS scores between the two groups before treatment，there was no significance in differences(P＞0.05).Conclusion：The therapy of Guipi tang for anemia related to gastric cancer can increase the levels of hemoglobin and erythrocyte，and improve the immune function of patients，which has better effect in improving anemia than western routine treatment of iron supplement.