Objective：To observe the effect of Sini tang on blood pressure variability of patients with septic shock.Methods：Selected 40 cases of patients with septic shock who were admitted to our hospital，and divided them into the control group and the observation group according to the random number table method，20 cases in each group.The control group received conventional rescue，while the observation group additionally received Sini tang based on the treatment of the control group.Observed changes in blood pressure and blood pressure variability before and after treatment in both groups.Results：Before treatment， there was no significant difference being found in the comparisons of systolic blood pressure(SBP)and diastolic blood pressure(DBP)between the two groups(P＞0.05).At the 3rd，6th，and 9thhours after treatment，the SBP and DBP in the two groups were increased when compared with those before treatment(P＜0.05).At the 3rdhour after treatment，the SBP and DBP in the observation group were higher than those in the control group(P＜0.05).At the 6thhour after treatment，the SBP in the observation group was higher than that in the control group(P＜0.05)；there was no significant difference being found in the comparison of DBP between the two groups(P＞0.05).At the 9thhour after treatment，there was no significant difference being found in the comparisons of SBP and DBP between the two groups(P＞0.05).After five-day treatment，the standard deviation of SBP and DBP at daytime，the standard deviation of SBP and DBP at night，the variation coefficient of SBP and DBP at daytime，and the variation coefficient of SBP and DBP at night in the observation group were all lower than those in the control group(P＜0.05).There was no significant difference being found in the comparison of early morning blood pressure surge between the two groups(P＞0.05).Conclusion：Sini tang can accelerate the blood pressure rise of patients with septic shock and effectively improve the blood pressure variability.