Objective：To observe the clinical effect of integrated Chinese and western medicine nursing after operation for open fractures of extremities.Methods：Divided 120 cases of patients with open fractures of extremities into two groups randomly，60 cases in each group.The control group was given antibiotics and routine treatment after fracture operation，while the observation group was additionally given the integrated Chinese and western medicine nursing.Observed the clinical effect，score changes of self-rating depression scale(SDS)and self-rating anxiety scale(SAS)in the two groups and satisfaction degree of nursing.Results：The excellent and good rate of clinical effect was 95.00%in the observation group and 68.33%in the control group，compared the two groups，difference being significant(P＜0.05).After nursing intervention，the SAS and SDS scores in the two groups were lower than those before the nursing(P＜0.05)；and the decrease of SAS and SDS scores in the observation group was more significant than that in the control group(P＜0.05).The satisfaction rate of nursing was 100%in the observation group and 85.0%in the control group，compared the two groups，difference being significant(P＜0.05).Conclusion：The model of integrated Chinese and Western medicine nursing has good effects when applied in patients with open fractures of extremities and can improve the depression and anxiety of patients.It is worthy of clinical promotion and application.