To observe the curative effect of Gegen Qinlian tang combined with routine therapy for children with rotavirus enteritis and the effect on antibody negative conversion of rotavirus enteritis.Methods：Enrolled 60 cases of children with rotavirus enteritis(hygropyretic diarrhea)and divided them into the control group and the observation group with 30 cases in each group according to the random number table.Both groups were both given routine intervention measures，intravenous infusion of ribavirin injection，and the observation group was treated with Gegen Qinlian tang.The two groups were treated continuously for 7 days.Evaluated the symptom scores of damp-heat diarrhea in children in the two groups before and after treatment.Recorded the negative conversion conditions of rotavirus at 3 and 7 days of treatment，defervescence time，checking diarrhea time，negative conversion time of rotavirus enteritis and the antiemetic time of the two groups，and compared the clinical effect of the two groups.Results：After treatment，the total effective rate of the observation group was 93.33%，which was higher than that of 66.67%in the control group，difference being significant(P＜0.05).The scores of brown smelly fecal diarrhea，scanty dark urine and thirst in the two groups were lower than those before treatment(P ＜0.01)，and the scores of each symptom in the observation group were lower than those in the control group(P ＜ 0.01).The negative conversion rate of rotavirus in the observation group was higher than that in the control group at 3 and 7 days of treatment(P ＜ 0.05).The defervescence time，antiemetic time，checking diarrhea time and negative conversion time of rotavirus enteritis of the observation group were shorter than those of the control group(P＜0.01).Conclusion：The additional application of Gegen Qinlian tang on the basis of routine therapy for children with rotavirus enteritis can accelerate the improvement of symptoms and increase the curative effect.