逍遥散加减治疗气滞血瘀型子宫腺肌症临床研究
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R711.74

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Clinical Study on Modified Xiaoyao Powder for Adenomyosis of Blood Stasis due to Qi Stagnation Type
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    摘要:

    目的:观察逍遥散加减对气滞血瘀型子宫腺肌症(AM)肿瘤标记物及中医证候的影响。方法:将气滞血瘀型AM患者78例,按随机数字表法分成2组,对照组39例口服布洛芬缓释胶囊,观察组39例在对照组的基础上加服逍遥散加减,观察患者临床疗效及不良反应状况,检测患者治疗前后子宫体积、经量及血清癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原125(CA125)含量的改变状况。结果:痛经总有效率观察组为89.74%,对照组为61.54%,2组比较,差异有统计学意义(P<0.05)。中医证候总有效率观察组为84.62%,对照组为66.67%,2组比较,差异有统计学意义(P<0.05)。治疗后2组患者子宫体积及痛经评级较治疗前明显下降(P<0.05),且观察组上述指标改善优于对照组(P<0.05)。治疗后2组血清CEA、CA199、CA125含量较治疗前明显降低(P<0.05),且观察组上述指标均低于对照组(P<0.05)。不良反应率观察组为12.82%,对照组为30.77%,2组比较,差异有统计学意义(P<0.05)。结论:逍遥散加减可改善气滞血瘀型AM患者痛经等临床症状,降低中医证候积分及血清肿瘤标记物含量,且安全性较高。

    Abstract:

    To observe the effect of modified Xiaoyao powder on tumor markers and Chinese medicine syndrome of adenomyosis(AM)of blood stasis due to qi stagnation type.Methods:A total of 78 cases of AM patients of blood stasis due to qi stagnation type were divided into two groups according to the random number table method,39 cases in each group.The control group was given oral administration of ibuprofen sustained-release capsules,and the observation group was additionally treated with modified Xiaoyao powder based on the treatment of the control group.The clinical effect and adverse reactions were observed; the changes of the uterine volume, the menstrual amount and the content of carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9)and carbohydrate antigen 125(CA125)in serum before and after treatment were detected.Results:The total effective rate of dysmenorrhea was 89.74%in the observation group and 61.54%in the control group,the difference being significant(P<0.05).The total effective rate of Chinese medicine syndrome was 84.62%in the observation group and 66.67%in the control group,the difference being significant(P<0.05).After treatment,the uterine volume and the levels of dysmenorrhea in the two groups were significantly decreased when compared with those before treatment(P < 0.05),and the improvement of the above indexes in the observation group was better than that in the control group(P < 0.05).After treatment,the content of CEA,CA19-9 and CA125 in serum in the two groups was significantly decreased when compared with that before treatment(P < 0.05),and the above indexes in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions was 12.82%in the observation group and 30.77%in the control group,the difference being significant(P< 0.05).Conclusion:Modified Xiaoyao powder can alleviate the clinical symptoms such as dysmenorrhea in AM patients of blood stasis due to qi stagnation type,reduce Chinese medicine syndrome scores and the content of serum tumor markers with high safety.

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杨翠峰,郝连欣.逍遥散加减治疗气滞血瘀型子宫腺肌症临床研究[J].新中医,2019,51(10):63-66

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  • 在线发布日期: 2019-10-11
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