To observe the clinical effect of Xijiao Dihuang tang for Henoch-Schonlein purpura nephritis.Methods：Divided 60 cases of patients with Henoch-Schonlein purpura nephritis into two groups randomly，27 cases in the control group and 33 cases in the observation group.The control group received routine western medicine treatment，while the observation group additionally received modified Xijiao Dihuang tang.The treatment of both groups lasted for 2 months.Observed and compared the clinical effect and changes in indexes of renal function[blood urea nitrogen(BUN)，serum creatinine(Scr)， 24-hour urinary protein(24h Upro)， blood uric acid(BUA)， urinary albumin(mAlb)]， indexes of coagulation function[plasma prothrombin time(PT)，activated partial thromboplastin time(APTT)， thrombin time(TT)， fibrinogen content(FIB)]，urine red blood cell count and proportions of T lymphocyte subsets and NK cells in both groups before and after treatment.Results：The total effective rate was 86.8%in the observation group and 62.5%in the control group，difference being significant(P ＜ 0.05).After treatment，the contents of Scr，BUN，24h Upro excretion，BUA and mAlb and urine red blood cell count in both groups were lower than those before treatment(P ＜ 0.05)，and each index above in the observation group was lower than that in the control group(P ＜ 0.05).After treatment，APTT，PT and TT in both groups were longer than those before treatment(P ＜ 0.05)，and the content of FIB was lower than that before treatment(P ＜ 0.05)；each index above in the observation group was improved better than that in the control group(P ＜ 0.05).After treatment，the levels of CD4+/CD8+and CD16+CD56+NK cells in the observation group were higher than those in the control group(P ＜ 0.05)，the level of CD8+T cells was lower than that in the control group(P ＜ 0.05)，and there was no significant difference being found in the levels of CD3+T cells and CD4+T cells in both groups(P＞0.05).The differential values in the levels of CD4+T cells and CD3+T cells in the peripheral blood of the observation group before and after treatment were respectively lower than those of the control group，and the differential values in the levels of CD4+/CD8+and CD16+CD56+NK cells in the peripheral blood of the observation group before and after treatment were respectively higher than those of the control group，differences being significant(P＜0.05).Conclusion：Xijiao Dihuang tang has significant clinical effect in treating Henoch-Schonlein purpura nephritis，which can effectively improve the renal function，immune function and coagulation function.