To observe the clinical effect of Wenfei Sanhan Diyin tang combined with ginger therapy on the bladder meridian for acute exacerbation of chronic obstructive pulmonary disease of external cold with internal fluid retention type.Methods：A total of 140 cases of patients were randomly divided into the experiment group and the control group，70 cases in each group.Both groups were given routine western medicine treatments such as oxygen therapy，triple aerosol inhalation，suppressing cough and resolving phlegm，arresting convulsions and calming panting，correcting water-electrolyte imbalance and antibiotics； the control group was additionally treated with ginger therapy on the bladder meridian，and the experiment group was additionally treated Wenfei Sanhan Diyin tang based on the treatment of the control group.Both groups were treated for two weeks.The scores of external cold with internal fluid retention syndrome and the BODE indexes in the two groups were evaluated； the lung function indexes including forced expiratory volume in one second(FEV1)， the percentage of predicted value of FEV1(FEV1%)and the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC%)， the blood gas indexes including partial pressure of oxygen(PaO2)， partial pressure of carbon dioxide(PaCO2)and oxygen saturation(SaO2)，and inflammatory indexes including procalcitonin(PCT)，interleukin-8(IL-8)， tumor necrosis factor-α(TNF-α)and serum amyloid A(SAA)in the two groups were detected.Results：After treatment，the scores of BODE indexes and external cold with internal fluid retention syndrome in the two groups were decreased when compared with those before treatment(P ＜ 0.05)，and the above two scores in the experiment group were lower than those in the control group(P ＜ 0.05).After treatment，the indexes of PCT，IL-8，TNF-α and SAA in serum in the two groups were decreased when compared with those before treatment(P ＜ 0.05)，and the above indexes in the experiment group were lower than those in the control group(P ＜ 0.05).After treatment，the lung function indexes including FEV1，FEV1%and FEV1/FVC%in the two groups were increased when compared with those before treatment(P ＜ 0.05)，and the above indexes in the experiment group were higher than those in the control group(P ＜ 0.05).After treatment，the indexes of PaO2and SaO2 in the two groups were increased when compared with those before treatment(P ＜ 0.05)，while the indexes of PaCO2were decreased when compared with those before treatment(P ＜ 0.05)；the improvement of the above indexes in the experiment group was superior to that in the control group(P＜0.05).Conclusion：The therapy of Wenfei Sanhan Diyin tang combined with ginger therapy on the bladder meridian in treating acute exacerbation of chronic obstructive pulmonary disease of external cold with internal fluid retention type can significantly improve the lung function and the blood gas indexes and reduce the inflammatory indexes in serum，thereby promoteing the rehabilitation.