To observe the effect of retention enema with Qingre Qushi prescription combined with mesalazine on the coagulation function and inflammatory cytokines of patients with ulcerative proctitis of large intestinal dampness-heat type at active stage.Methods：A total of 84 cases of patients with ulcerative proctitis of large intestinal dampness-heat type at active stage were divided into the observation group and the control group according to the random number table method，42 cases in each group.The control group was treated with mesalazine enteric-coated tablets，and the observation group was additionally treated with retention enema with Qingre Qushi prescription based on the treatment of the control group.Both groups were treated for four weeks.The improvement of the scores of clinical symptoms including abdominal pain，diarrhea as well as stool containing mucus，pus and blood，the indexes of the coagulation function including prothrombin time(PT)，activated partial thromboplastin time(APTT)， fibrinogen(FIB)and D-dimer(D-D)， and the inflammatory cytokines in serum including interleukin-6(IL-6)，interleukin-8(IL-8)and interleukin-10(IL-10)in the two groups was observed and recorded；the clinical effect in the two groups was compared.Results：The total effective rate was 90.48%in the observation group，significantly higher than that of 71.42%in the control group(χ2=4.941，P ＜ 0.05).After treatment，the scores of abdominal pain，diarrhea and mucus and stool containing mucus，pus and blood in the two groups were decreased when compared with those before treatment(P ＜ 0.05)；the above scores in the observation group were lower than those in the control group(P ＜ 0.05).After treatment，the indexes of PT，APTT，FIB and D-D in the two groups were decreased when compared with those before treatment(P ＜ 0.05)；the above indexes in the observation group were lower than those in the control group(P ＜ 0.05).After treatment，the levels of IL-6 and IL-8 in serum in the two groups were decreased when compared with those before treatment(P ＜ 0.05)，while the levels of IL-10 were increased when compared with those before treatment(P ＜ 0.05)；the improvement of the levels of inflammatory cytokines in serum in the observation group was superior to that in the control group(P＜0.05).Conclusion：The therapy of retention enema with Qingre Qushi prescription combined with mesalazine can regulate the disorder of the indexes of coagulation function and the expression of inflammatory cytokines in serum of patients with ulcerative proctitis of large intestinal dampness-heat type at active stage，which can help relieve the clinical symptoms and promote the rehabilitation of the disease.