红景天乳膏联合木丹颗粒治疗2型糖尿病周围神经病变临床研究
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R587.2

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兰州市科技计划顶目 (2017-4-1)


Clinical Study on Hongjingtian Cream Combined with Mudan Capsules for Type 2 Diabetic Peripheral Neuropathy
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    摘要:

    目的:观察分析红景天乳膏联合木丹颗粒对2型糖尿病周围神经病变(Diabetic peripheral neuropathy,DPN)的临床症状改善、总症状评分(Total symptoms score,TSS)降低情况,以及对足部感觉震动阈值(Vibrating perception threshold,VPT)、神经传导速度(Nerve conduction velocity,NCV)等的影响,为DPN的治疗提供有力依据。方法:将74例DPN患者随机分为3组。对照Ⅰ组25例给予常规治疗;对照Ⅱ组25例在常规治疗基础上给予木丹颗粒;治疗组24例在常规治疗基础上给予红景天乳膏联合木丹颗粒。观察3组临床症状、TSS改善情况、VPT及NCV的变化。结果:治疗4周后,与对照Ⅰ组、Ⅱ组比较,治疗组患者的临床症状改善、TSS、VPT明显下降,差异均有统计学意义(P<0.01,P<0.05);NCV明显升高,差异有统计学意义(P<0.01,P<0.05)。结论:红景天乳膏联合木丹颗粒对2型DPN患者疗效显著,可明显改善患者各种临床症状,降低TSS及VPT,提高NCV,且安全性较高,值得临床进一步研究推广。

    Abstract:

    To observe and analyze the effect of Hongjingtian Cream combined with Mudan Capsules on the improvement of clinical symptoms and the decrease of the total symptom scores(TSS)in patients with type 2 diabetic peripheral neuropathy,and its effect on vibrating perception threshold(VPT)and nerve conduction velocity(NCV),so as to provide references for the treatment of diabetic peripheral neuropathy(DPN).Methods:A total of 74 cases of patients with DPN were randomly divided into three groups.The ControlⅠ group(25 cases)received conventional treatment; the ControlⅡ group(25 cases)was additionally treated with Mudan Capsules based on conventional treatment;the treatment group(24 cases)was additionally treated with Mudan Capsules combined with Hongjingtian Cream based on conventional treatment.The clinical symptoms,improvement of TSS and changes of VPT and NCV were observed in the three groups.Results:Four weeks after treatment, the improvement of clinical symptoms, TSS and VPT in the treatment group were significantly decreased when compared with those in the ControlⅠandⅡ groups,differences being significant(P<0.01,P<0.05).The NCV was significantly increased,the difference being significant(P<0.01,P<0.05).Conclusion:The therapy of Hongjingtian Cream combined with Mudan Capsules has significant therapeutic effect in treating patients with DPN,which can improve the clinical symptoms of them,reduce TSS and VPT,and improve NCV.It is also safe and worthy of further clinical research and promotion.

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王晶,傅松波,郭潇,范力.红景天乳膏联合木丹颗粒治疗2型糖尿病周围神经病变临床研究[J].新中医,2019,51(10):143-147

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  • 在线发布日期: 2019-10-11
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