To observe the clinical effect of qi-supplementing and yin-nourishing prescription for diabetes mellitus(GDM)during pregnancy and its effects on adipokines factors， islet β-cell function and pregnancy outcomes.Methods：Divided 130 cases of GDM patients randomly into two groups with 65 cases in each group.The control group underwent routine diet control；if the blood glucose was not effective，insulin was administered.The observation group was additionally given qi-supplementing and yin-nourishing prescription on the basis of the treatment in the control group.Compared the improvement of serum adipokines factors and islet β-cell function and pregnancy outcomes in the two groups before and after treatment.Results： After treatment， the fasting blood glucose(FBG)， postprandial 2 h blood glucose，glycosylated hemoglobin(HbA1c)， fasting insulin(FINS)， insulin resistance index(HOMA-IR)in the two groups were all decreased when compared with those before treatment(P ＜ 0.05)；the decrease in the observation group was more obvious(P ＜ 0.05).After treatment，the adiponectin(ADPN)in the two groups were higher than those before treatment(P ＜ 0.05)；visfatin，resistin，leptin(LP)and retinol binding protein-4(RBP-4)were all decreased when compared with those before treatment(P＜0.05).The improvement in the observation group was more obvious(P＜0.05).There was significant deference being found in the comparison of the incidence of each adverse pregnancy outcome in the observation group after treatment with that in the control group(P＜0.05).Conclusion：The application of qi-supplementing and yin-nourishing prescription for patients with diabetes during pregnancy can significantly improve serum adipokines factors and islet β cell function and reduce the incidence of adverse pregnancy outcomes.