补肾化瘀方联合宫腔粘连分离术治疗宫腔粘连型月经过少疗效观察及对内膜厚度的影响
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R713.4

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Observation of Bushen Huayu Prescription Combined with Transcervical Resection of AdhesionforHypomenorrheaofIntrauterineAdhesionsTypeandItsEffecton Endometrial Thickness
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    摘要:

    目的:观察补肾化瘀方联合宫腔粘连分离术(TCRA)治疗宫腔粘连(IUA)型月经过少(闭经)患者的疗效及对内膜厚度的影响。方法:将97例IUA型月经过少患者按照就诊时间进行编号,随机分为治疗组49例和对照组48例。2组患者均在月经干净后3~7天,闭经者无时间要求,进行TCRA。术后第3天,治疗组服用补肾化瘀方,对照组服用补佳乐,连续治疗3个月经周期。观察并记录患者治疗前后月经经期、量、色、质情况;治疗前后患者月经第14天、月经第25天子宫内膜厚度;宫腔粘连程度;不同时间体内肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)变化。结果:治疗后,2组中医证候积分较治疗前均下降,差异有统计学意义(P<0.05);治疗后2组间比较,差异有统计学意义(P<0.05)。治疗后,2组第14天、第25天子宫内膜厚度较治疗前均增加,且治疗组增加明显,差异有统计学意义(P<0.05)。治疗后,2组宫腔粘连评分均下降,且治疗组下降更为明显,差异有统计学意义(P<0.05)。2组术后1 h,TNF-α、IL-6含量较术前均升高,术后3天和术后7天TNF-α、IL-6含量较术前均降低,且治疗组降低更为明显,差异有统计学意义(P<0.05)。治疗后2组间妊娠情况比较,差异无统计学意义(P>0.05)。2组患者研究期间无明显不良反应发生。结论:补肾化瘀方联合TCRA可有效修复子宫内膜厚度,增加月经量,改善经期量、色、质,减轻TCRA术后炎症反应。

    Abstract:

    To observe the curative effect of Bushen Huayu prescription combined with transcervical resection of adhesion(TCRA)for patients with hypomenorrhea(amenorrhea)of intrauterine adhesions(IUA)type and its effect on endometrial thickness.Methods:A total of 97 cases of patients with hypomenorrhea of IUA type were numbered according to the visiting time and were randomly divided into the treatment group and the control group,49 and 48 cases in each group respectively.Patients in the two groups were treated with TCRA three to seven days after menstruation,and there was no time restriction for the patients with amenorrhea.On the 3rdday after surgery,the treatment group was treated with Bushen Huayu prescription,and the control group was treated with Bujiale.Both groups were treated for three menstrual cycles.Before and after treatment,the duration,amount,colors and quality of menstruation,the endometrial thickness on the 14th and 25thday in menstrual periods,the degree of IUA,and the changes of tumor necrosis factor-α (TNF-α)and interleukin-6(IL-6)at different time were observed and recorded.Results:After treatment,the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,the difference being significant(P < 0.05);the comparison of the scores in the two groups showed significance in the difference(P < 0.05).After treatment,the endometrial thicknesses on the 14thand 25thday in the two groups were increased when compared with those before treatment,and the increase in the treatment group was more obvious,the difference being significant(P < 0.05).After treatment,the scores of IUA in the two groups were decreased,and the decrease in the treatment group was more obvious,the difference being significant(P<0.05).One hour after surgery,the contents of TNF-α and IL-6 in the two groups were increased when compared with those before surgery;three and seven days after surgery,the above two contents were decreased when compared with those before treatment,and the decrease in the treatment group was more obvious,the difference being significant(P < 0.05).After treatment,there was no significant difference being found in the comparison of the pregnancy in the two groups(P>0.05).There was no obvious adverse reaction in the two groups during the study.Conclusion:The therapy of Bushen Huayu prescription combined with TCRA can effectively repair the endometrial thickness,increase menstrual amount, improve the amount, color and quality of menstrual blood, and reduce postoperative inflammatory reaction of TCRA.

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杨国红,王立霞.补肾化瘀方联合宫腔粘连分离术治疗宫腔粘连型月经过少疗效观察及对内膜厚度的影响[J].新中医,2019,51(10):169-172

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  • 在线发布日期: 2019-10-11
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