To explore the clinical effect of the therapy of Busui Shengxue Tang combined with cyclosporine A soft capsules and stanzoll tablets in the treatment of chronic aplastic anemia.Methods：A total of 65 patients with chronic aplastic anemia were randomly divided into two groups.Thirty two patients in the control group were treated with cyclosporine A soft capsules and stanzoll tablets.Thirty three patients in the observation group were additionally treated with Busui Shengxue Tang based on the treatment of the control group.Both groups were treated for six months.The clinical effect，the scores of symptoms before and after treatment(palpitations，fatigue，dizziness，cold body and cold extremities，complexion，lips，nails，soreness and weakness of waist and knees)，and the changes in the levels of the tumor necrosis factor alpha- α(TNF-α)，interferon-γ (IFN- γ)，basic fibroblast growth factor(bFGF)，member A in Rho family of protein(Rho-A)in serum were observed and compared，and the adverse reactions were statistically analyzed in the two groups.Results：The total effective rate was 93.94%in the observation group and 71.88%in the control group，the difference being significant(P＜0.05).After treatment，the scores of palpitations，fatigue，dizziness，cold body and cold extremities，complexion，lips，nails，soreness and weakness of waist and knees were decreased when compared with those before treatment(P ＜ 0.05)，and the above scores in the observation group were lower than those in the control group(P ＜ 0.05).After treatment，the levels of TNF-α and IFN-γ in serum were decreased when compared with those before treatment(P ＜ 0.05)，while levels of bFGF and Rho-A were increased when compared with those before treatment(P ＜ 0.05)，and the improvement of the above indexes in the observation group was better than that in the control group(P＜0.05).The incidence of adverse reactions was 18.18%(6/33)in the observation group and 15.63%(5/32)in the control group，there being no statistically significant difference between the two groups(P＞0.05).Conclusion：The therapy of Busui Shengxue Tang combined with cyclosporine A soft capsules and stanzoll tablets， has significant effect in treating chronic aplastic anemia， and can improve the levels of TNF-α，IFN-γ，bFGF and Rho-A in serum in patients with high safety.