To observe the clinical effect of Chinese herbal fumigation combined with gabapentin and hemoperfusion for pruritus in hemodialysis patients.Methods：Divided 60 cases of uremia patients with maintenance hemodialysis into two groups randomly，with 30 cases in each group.Both groups received the treatment of hemoperfusion as well as the oral administration of gabapentin，while the observation group additionally received Chinese herbal fumigation.Observed the degree of pruritus evaluated by visual analogue scale(VAS)and the general therapeutic efficiency in the two groups before and after treatment；observed the changes of serum phosphorus，blood calcium，parathyroid hormone(PTH)and serum β2microglobulin(β2-MG)before and after treatment.Results：The total effective rate in the observation group was 90.00%，being higher than that of 76.67%in the control group，difference being significant(P＜0.05).VAS scores in both groups were lower than those before treatment，difference being significant(P ＜ 0.05).Compared with that in the control group，VAS score in the observation group after treatment was decreased，difference being significant(P＜0.05).Compared with those before treatment，blood calcium and phosphorus were improved in both groups after treatment，difference being significant(P＜0.05).Compared with that in the control group，blood calcium was significantly increased and serum phosphorus was decreased in the observation group after treatment，difference being significant(P＜0.05).Compared with those before treatment，PTH and β2-MG were improved in both groups after treatment，difference being significant(P ＜ 0.05).Compared with those in the control group，PTH and β2-MG in the observation group after treatment were reduced，difference being significant(P＜0.05).Conclusion：The application of Chinese herbal fumigation combined with hemoperfusion and oral administration of gabapentin achieves satisfactory results in the treatment for pruritus in hemodialysis patients，improves the quality of life of patients and relieves the pain caused by pruritus.