中药药浴联合窄谱中波紫外线照射治疗斑块型银屑病临床研究
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R758.63

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温州市卫生局课题(20150322)


Clinical Study of Chinese Medicine Medicated Bath Combined with Narrow-band Ultraviolet B Irradiation for Psoriasis of Plaque Type
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    摘要:

    目的:观察中药药浴联合窄谱中波紫外线照射治疗斑块型银屑病的临床疗效。方法:选取110例斑块型银屑病患者,按随机数字表法分为观察组和对照组各55例。对照组给予窄谱中波紫外线照射治疗,观察组在对照组基础上联合中药药浴治疗,2组均治疗8周。治疗后对比2组临床疗效,观察患者皮损程度、生活质量的改善情况及炎症反应的控制情况。结果:观察组总有效率89.09%,高于对照组的72.73%,差异有统计学意义(P<0.05)。治疗后,2组皮肤皮肌炎活动和严重程度指数(CDASI)、皮肤病生活质量指数(DLQI) 评分均较治疗前降低(P<0.05),观察组CDASI、DLQI评分均低于对照组(P<0.05)。与治疗前比较,治疗后观察组C-反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α) 水平均降低(P<0.05)。治疗后3项炎症因子水平组间比较,差异均有统计学意义(P<0.05)。结论:中药药浴联合窄谱中波紫外线照射治疗斑块型银屑病疗效显著,可以改善患者的皮损,提高生活质量,减轻炎症反应,值得临床推广应用。

    Abstract:

    To observe the clinical effect of Chinese medicine medicated bath combined with narrow-band ultraviolet B irradiation for psoriasis of plaque type.Methods:Selected 110 cases of patients with psoriasis of plaque type and divided them into the observation group and the control group according to random number table,with 55 cases in each group.The control group was given narrow-band ultraviolet B irradiation,while the observation group was additionally given Chinese medicine medicated bath.Both groups were treated for 8 weeks.After treatment,compared the clinical effect in the two groups and observed the degree of skin lesions improvement of quality of life and controlling situation of inflammatory response in patients.Results:The total effective rate in the observation group was 89.09%,being higher than that of 72.73%in the control group,difference being significant(P < 0.05).After treatment,the scores of cutaneous dermatomyositis activity and severity index(CDASI)and dermatology life quality index(DLQI)in the two groups were lower than those before treatment(P < 0.05),while the scores of CDASI and DLQI in the observation group were lower than those in the control group(P <0.05).After treatment,the levels of C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α (TNF-α)in the observation group were reduced when compared with those before treatment(P < 0.05).After treatment,there were significant differences being found in the comparison of the levels of three inflammatory factors in the two groups(P<0.05).Conclusion:The application of Chinese medicine medicated bath combined with narrow-band ultraviolet B irradiation has obvious curative effect in treating psoriasis of plaque type,which can improve the skin lesions of patients,enhance quality of life and relieve inflammaory response.It is worthy of clinical promotion and application.

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郑明警,李温如,颜聪颖,叶海东.中药药浴联合窄谱中波紫外线照射治疗斑块型银屑病临床研究[J].新中医,2019,51(10):217-220

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  • 在线发布日期: 2019-10-11
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