To observe the clinical effect of Qingre Zhitong Chinese medical prescription for reversible acute pulpitis.Methods：Enrolled 90 cases of patients with reversible acute pulpitis of wind-fire type in the department of oral medicine in our hospital and divided them，into the control group and the observation group randomly，with 45 cases in each group.The control group was given a permanent filling treatment after temporarily sealing carious holes by clove oil cotton balls for two weeks.The observation group was additionally treated with the combined application of Qingre Zhitong Chinese medicine.Observed the clinical effect，correlated biochemical indexes，pain relief effect and adverse reactions in the two groups.Results：There was significant difference being found in the comparison of the clinical effect in the two groups(P ＜0.05)and the observation group was better than the control group.The visual analogue scale(VAS)of pain after treatment in the observation group was lower than that in the control group，difference being significant(P ＜ 0.05).After treatment，white blood cell counts(WBC)in both groups were decreased evidently，significant differences being found in the comparison between the two groups(P ＜ 0.05).After treatment，compared the levels of alanine aminotransferase(ALT)and creatinine(Cr)in the two groups with those before treatment，no significant differences was found in the comparison between the two groups(P ＞ 0.05)，which suggests that there were no abnormal changes in urine routine and liver and kidney function tests in the two groups.Conclusion：The application of Qingre Zhitong Chinese medicine can effectively relieve dental pulpitis and pain in patients with acute pulpitis of wind-fire type.