To observe the clinical effect of the integrated acupuncture and moxibustion regimen in treating mild-to-moderate depression and its effect on the quality of life of patients.Methods：A total of 101 patients with mild-to-moderate depression were randomly divided into the comprehensive group，the acupuncture and moxibustion group and the acupuncture group.The comprehensive group was treated with integrated acupuncture and moxibustion regimen；the acupuncture and moxibustion group was treated with acupuncture and moxibustion with moxa cone，and the acupuncture group was solely treated with needling.All groups were treated once a day and twice a week.The course of treatment in the three groups was twelve weeks.Before and after treatment and one month after treatment，the scores of Hamilton Depression Scale(HAMD)and Short Form 36-item Health Survey(SF-36)were evaluated and the clinical effect was observed.Results：After treatment and one month after treatment，scores of HAMD in the three groups were decreased when compared with those before treatment，the difference being significant(P ＜ 0.05).After treatment，the HAMD scores in the comprehensive group and the acupuncture and moxibustion group were lower than those in the acupuncture group(P＜0.05).One month after treatment，the HAMD score in the comprehensive group was lower than those in the acupuncture and moxibustion group and the acupuncture group(P ＜ 0.05).After treatment，the total effective rate was 88.24% in the comprehensive group，82.35%in the acupuncture and moxibustion group，and 51.52%in the acupuncture group.The ones in comprehensive group and acupuncture group were significantly higher than that in the acupuncture group(P＜0.05).One month after treatment，the total effective rate was 79.41%in the comprehensive group，47.06%in the acupuncture and moxibustion group，and 42.42%in the acupuncture group.The one in the comprehensive group was significantly higher than those in the acupuncture group and acupuncture and moxibustion group(P＜0.05).After treatment and one month after treatment，SF-36 scores of all dimensions in the three groups were increased when compared with those before treatment(P＜0.05).After treatment and one month after treatment，SF-36 scores of all dimensions in the comprehensive group were higher than those in the acupuncture and moxibustion group and the acupuncture group(P＜0.05).Conclusion：The integrated acupuncture and moxibustion scheme hassignificant short-term and long-term effect in treating mild-to-moderate depression，and can improve the quality of life of patients，which is worthy of clinical promotion.