To observe the effect of scalp acupuncture combined with ganglioside for ischemic stroke on neurological functional rehabilitation in early and middle stage.Methods：Divided 94 cases of patients into two groups randomly，46 cases in the control group and 48 cases in the observation group.The control group received aspirin enteric-coated tablets and simvastatin tablets via oral administration and monosialotetrahexosyl ganglioside sodium via intramuscular injection for 6 weeks continuously，while the observation group additionally received scalp acupuncture 5 days a week for 6 weeks.Before and after treatment， assessed the scores of neurological deficit scale(NDS)， Fugl-Meyer assessment scale(FMA)，activity of daily living(ADL)and qi deficiency and blood stasis syndrome，and statistically analyzed the clinical effect in both groups.Results：After rank-sum test，the clinical effect in the observation group was better than that in the control group，difference being significant(P ＜ 0.05).After treatment，the scores of NDS and qi deficiency and blood stasis syndrome in both groups were lower than those before treatment(P ＜ 0.05)，the scores of ADL and FMA were significantly higher than those before treatment(P ＜ 0.05)；each index above in the observation group was improved more significantly than that in the control group(P＜0.05).Conclusion：The application of scalp acupuncture combined with ganglioside for ischemic stroke in early and middle stage can promote the recovery of neurological function，enhance the exercise capacity and activity of daily living of patients and alleviate clinical symptoms，which is worthy of clinical application.