Objective： To observe the curative effectofSimotang oral liquid combined with Baohe pills for gastrointestinal dysfunction in newborns.Methods：A total of 88 cases of newborns with gastrointestinal dysfunction were divided into the observation group and the control group according to the random number table method，45 and 43 cases in each group respectively.Both groups received routine symptomatic treatments；the control group was additionally treated with medilac-vita，and the observation group was additionally treated with Simotang oral liquid combined with Baohe pills.After treatment for 14 days， the changes of levels of motilin(MTL)and gastrin(GAS)in plasma， the improvement of clinical symptoms and the clinical effect in the two groups were compared.Results：Before treatment，there was no significant difference being found in the comparison of the levels of MTL and GAS in plasma in the two groups(P ＞ 0.05).After treatment，the levels of MTL and GAS in plasma in the two groups were significantly increased，and the levels in the observation group were significantly higher than those in the control group(P ＜ 0.05)；the clearance time of meconium，the disappearance time of symptoms，the healing time and the time when reaching full enteral feeding in the observation group were significantly shorter than those in the control group(P ＜ 0.05)；the total effective rate was 95.56% in the observation group，significantly higher than that of 74.42% in the control group，the difference being significant(P＜0.05).Conclusion：The therapy of Simotang oral liquid combined with Baohe pills in treating gastrointestinal dysfunction in newborns can effectively improve the levels of MTL and GAS in plasma and the clinical symptoms，with significant clinical effect，which is worthy of promotion and application.