Objective：To observe the clinical effect of Neixiao Louli pills combined with levothyroxine sodium tablets for benign thyroid nodules.Methods：Divided 108 cases of patients with benign thyroid nodules who had qi depression and phlegm obstruction syndrome into the control group and the observation group randomly，54 cases in each group.Both groups received the oral administration of levothyroxine sodium tablets，while the observation group additionally received Neixiao Louli pills.The treatment of both groups lasted for 12 weeks.Detected the maximal diameter of cross section of thyroid nodules and the volume of nodules via B ultrasound in both groups，and assessed scores of qi depression and phlegm obstruction syndrome before and after treatment.The clinical effect in the two groups was compared.Results：After treatment，the clinical effect in the observation group was better than that in the control group，difference being significant(P＜0.05).The disappearance rate of nodules was 33.33% in the observation group，being higher than 16.67% in the control group，difference being significant(P＜0.05).The maximal diameter and the volume of nodules in both groups were decreased when comparing with those before treatment，and the scores of qi depression and phlegm obstruction syndrome were lower than those before treatment，differences being significant(P＜ 0.01).The maximal diameter and the volume of nodules in the observation group were smaller than those in the control group，and the scores of qi depression and phlegm obstruction syndrome were lower than those in the control group，differences being significant(P＜ 0.01).Conclusion：The application of Neixiao Louli pills combined with levothyroxine sodium tablets can reduce the size of thyroid nodules，alleviate clinical symptoms and promote the elimination of nodules.It has better clinical effect than the treatment with simple levothyroxine sodium tablets.