Objective： To observe the therapeutic effect of the additional application of modified Yushen Peiyuan prescription based on the estrogen-progesterone cycle therapy for irregular menstruation of spleen and kidney deficiency type.Methods：A total of 78 patients with irregular menstruation of spleen and kidney deficiency type were randomly divided into the Chinese medicine group and the conventional group.Both groups were adopted with estrogen-progesterone cycle therapy，and the Chinese medicine group was additionally treated with modified Yushen Peiyuan prescription.The treatment time in both groups was one menstrual cycle.The clinical effect and the levels of hormones including luteinizing hormone(LH)， estradiol(E2)and progesterone(P)in the two groups before and after treatment were compared， and the adverse reactions were observed.Results： After one menstrual cycle of treatment， the total effective rate was 94.87% in the Chinese medicine group，higher than that of 76.92% in the conventional group，the difference being significant(P＜ 0.05).The levels of LH，E2and P in the two groups were all increased when compared with those before treatment，and the above three levels in the Chinese medicine group were all higher than those in the conventional group，differences being significant(P＜0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P＞0.05).Conclusion：In treating patients with irregular menstruation of spleen and kidney deficiency type，the additional application of Yushen Peiyuan prescription based on estrogen-progesterone cycle therapy，can significantly improve the curative effect and their hormone levels with great drug safety.