Abstract：Objective：To observe the clinical effect of Xingnaojing injection in adjuvant therapy for acute exacerbation of chronic obstructive pulmonary disease(AECOPD) complicated with respiratory failure typeⅡ. Methods：A total of 200 case of patients with AECOPD complicated with respiratory failure typeⅡ were randomly divided into the observation group and the control group，100 cases in each group. The control group was given routine western medicine combined with noninvasive positive pressure ventilation， and the observation group was additionally treated with Xingnaojing injection based on the treatment of the control group. Both groups were continuously treated for seven days. The changes in the levels of interleukin- 6(IL-6)，interleukin-10(IL-10)，tumor necrosis factor-α(TNF-α)，oxygen partial pressure(PO2)，partial pressure of carbon dioxide(PCO2) and pH before and after treatment in the two groups were observed and compared. The scores of COPD assessment test(CAT) and total clinical effect were evaluated in the two groups. Results：The total effective rate was 91.00% in the observation group，and 80.00% in the control group，the difference being significant(P＜0.05). After treatment，the levels of IL-6，IL-10 and TNF-α in the two groups were significantly decreased when compared with those before treatment (P＜0.05)， and the three levels in the observation group were lower than those in the control group(P＜0.05). After treatment， the indexes of arterial blood gas， namely POB and PCO2 in the two groups were significantly improved when compared with those before treatment(P＜0.05)，and the improvement in the observation group was more significant than that in the control group(P＜0.05)；no significant change was found in the comparison of pH in the two groups before and after treatment(P＞0.05). After treatment，the scores of CAT in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the score in the observation group was lower than that in the control group(P＜ 0.05). Conclusion： Based on routine western medicine and noninvasive positive pressure ventilation， Xingnaojing injection has significant curative effect in the adjuvant therapy of AECOPD complicated with respiratory failure type Ⅱ， which can effectively inhibit inflammatory reaction，improve blood gas indexes，and thus enhance the quality of life.