Abstract：Objective：To observe the clinical effect of Danweining granules combined with quadruple therapy on gastric ulcer(GU) of dampness- heat obstructing the middle energizer type. Methods：A total of 74 GU patients of dampness- heat obstructing the middle energizer type were selected and divided into the observation group and the control group according to the random number table method. The control group was given quadruple therapy(amoxicillin， clarithromycin， bismuth potassium citrate and omeprazole)， while the observation group was given Danweining granules combined with quadruple therapy. Both groups were treated for two weeks. After treatment，the therapeutic effect of Chinese medicine syndromes and gastroscopy were compared between the two groups，the clearance of Helicobacter pylori(Hp) was detected，and the contents of epidermal growth factor(EGF) in gastric juice and prostagrandin 2(PGE2) in gastric mucosa were detected before and after treatment. Results：The total effective rate of Chinese medicine syndromes was 97.30% in the observation group， higher than that of 75.68% in the control group(P＜0.05). The total effective rate of gastroscopy was 97.30% in the observation group， higher than that of 81.08% in the control group(P＜0.05). After treatment， the Hp clearance rate was 86.49% in the observation group and 62.16% in the control group， the difference being significant(P＜0.05). After treatment， the contents of EGF in gastric juice and PGE2 in gastric mucosa in both groups were increased when compared with those before treatment(P＜0.05)，and the levels of the EGF and PGE2 in the observation group were higher than those in the control group(P＜0.05). Conclusion：The combination of Danweining granules and quadruple therapy in the treatment of GU patients of dampness- heat obstructing the middle energizer type， can improve the clinical effect， promote the Hp clearance，and decrease the level of EGF in gastric juice and PGE2 in gastric mucosa.