Abstract： Objective： To observe the effect of Yiqi Yangyin Huoxue Lishui prescription on lipid metabolism， hemorheology as well as the levels of high-sensitivity C-reactive protein(hs-CRP)，vascular endothelial growth factor(VEGF) and stromal cell derived factor- 1(SDF- 1) in serum in patients with diabetic retinopathy. Methods： A total of 116 cases of patients with diabetic retinopathy were divided into the observation group and the control group，58 cases in each group. Both groups were given routine treatment for diabetic；the control group was additionally treated with calcium dobesilate tablets， and the observation group was additionally treated with Yiqi Yangyin Huoxue Lishui prescription based on the treatment of the control group. The indexes of lipid metabolism and hemorheology as well as the levels of hs-CRP，VEGF and SDF-1 in serum were compared between the two groups. Results：Before treatment，there was no significant difference being found in the comparison of the levels of lipid metabolism indexes between the two groups(P＞0.05). After treatment，the levels of highdensity lipoprotein cholesterol(HDL-C) in the two groups were increased when compared with those before treatment，and the levels of low- density lipoprotein cholesterol(LDL- C)， triglyceride(TG) and total cholesterol(TC) were decreased when compared with those before treatment； the level of HDL- C in the observation group was higher than that in the control group， and the levels of LDL- C， TG and TC were lower； differences were significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of hemorheological indexes between the two groups(P＞0.05). After treatment， the whole blood viscosity of high shear， whole blood viscosity of low shear， plasma viscosity， platelet aggregation rate and erythrocyte deformation index in the two groups were decreased when compared with those before treatment，and the above indexes in the observation group were lower than those in the control group，differences being significant(P＜0.05). Before treatment， compared the levels of hs- CRP， SDF- 1 and VEGF in serum between the two groups，there was no significance in the difference(P＞0.05). After treatment，the levels of hs- CRP，SDF- 1 and VEGF in serum in the two groups were decreased when compared with those before treatment， and the three levels in the observation group were lower than those in the control group， differences being significant(P＜0.05). Conclusion： Yiqi Yangyin Huoxue Lishui prescription in treating diabetic retinopathy can inhibit the expression levels of hs- CRP，SDF- 1 and VEGF in serum and improve lipid metabolism，hemorheological indexes，which has good clinical effect.