Abstract： Objective： To observe the clinical effect of Huaban pills combined with aspirin enteric- coated tablets and atorvastatin calcium tablets for carotid atherosclerotic plaques. Methods： A total of 100 cases of patients with carotid atherosclerotic plaques were randomly divided into the treatment group and the control group， 50 cases in each group. In both groups， risk factors were routinely controlled. The control group was treated with aspirin enteric- coated tablets and atorvastatin calcium tablets，and the treatment group was additionally treated with Huaban pills based on the treatment of the control group. Both groups were treated for six months. The clinical effect，and the changes in Chinese medicine symptom scores， plaque scores， cerebrovascular events as well as the levels of the total cholesterol(TC)， triglyceride(TG)， highdensity lipoprotein cholesterol(HDL- C) and low- density lipoprotein cholesterol(LDL- C) in serum in the two groups were observed and compared. Results： The total effective rate was 86.00% in the treatment group and 44.00% in the control group， the difference being significant(P＜0.05). After treatment， the scores of Chinese medicine symptoms such as dizziness， lassitude in loin and knee， tinnitus， heaviness in head and body and twinge in head in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the above scores in the treatment group were significantly lower than those in the control group(P＜0.05). After treatment，the levels of TC，TG and LDL-C in serum in the two groups were significantly decreased when compared with those before treatment(P＜0.05)， and the levels of HDL- C were increased slightly(P＞0.05)； there was no significant difference being found in the comparisons of the above indexes between the two groups(P＞0.05). After treatment，the scores of carotid atherosclerotic plaques in both left and right sides in the two groups were decreased when compared with those before treatment(P＜0.05)， and the scores in the treatment group were lower than those in the control group(P＜0.05). After follow- up for six months， no cerebrovascular events occurred in the two groups. During the treatment，no treatment-related adverse reactions occurred in the two groups. Conclusion： The therapy of Huaban pills combined with aspirin enteric- coated tablets and atorvastatin calcium tablets for patients with carotid atherosclerotic plaques can significantly improve their clinical symptoms， reduce plaque scores and levels of blood lipid，and effectively prevent cerebrovascular events.