Abstract： Objective： To observe the effect of Fuzheng Huatan Huoxue prescription on progesterone and insulin resistance in patients with recurrent spontaneous abortion. Methods： A total of 102 cases of patients with recurrent spontaneous abortion were divided into the observation group and the control group according to the random number table method， 51 cases in each group. The control group was treated with dydrogesterone， and the observation group was additionally given Fuzheng Huatan Huoxue prescription based on the treatment of the control group. The clinical effect in the two groups was compared，and the levels of hormones，blood glucose and inflammatory factors in serum were detected. Results：The total effective rate was 82.35% in the observation group and 64.71% in the control group，the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the levels of progesterone(P) and human chorionic gonadotropin(HCG) in serum between the two groups(P＞0.05). At six weeks of gestation，the HCG levels in the two groups were increased when compared with those before treatment，and the levels of P and HCG in the observation group were higher than those in the control group；at 12 weeks of gestation，the levels of P and HCG in the two groups were increased when compared with those before treatment， and the HCG level in the observation group was higher than that in the control group，differences being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of insulin resistance index(HOMA-IR)，sex hormone binding globulin(SHBG)， vascular endothelial growth factor(VEGF)， interleukin- 10(IL- 10)， interleukin- 17(IL- 17) and interferon- γ(IFN- γ) between the two groups(P＞0.05). After treatment，the levels of VEGF，SHBG and IL- 10 in the two groups were increased when compared with those before treatment，and the levels of HOMA-IR，IL-17 and IFN-γ were decreased；the levels of VEGF，SHBG and IL-10 in the observation group were higher than those in the control group，and the levels of HOMA-IR，IL-17 and IFN-γ were lower；differences being significant(P＜0.05). Conclusion：Fuzheng Huatan Huoxue prescription for recurrent spontaneous abortion has significant curative effect，which can reverse insulin resistance， regulate levels of inflammatory factors and improve successful pregnancy rates.