Abstract：Objective：To observe the clinical effect of Xingnao Kaiqiao acupuncture manipulation combined with rat nerve growth factors for acute cerebral hemorrhage and its effect on the levels of inflammatory factors， brain natriuretic peptide (NBP) and copeptin in serum. Methods： A total of 116 cases of patients with acute cerebral hemorrhage were randomly divided into the observation group and the control group， 58 cases in each group. The control group was given basic treatment and injection of rat nerve growth factors，and the treatment group was additionally treated with Xingnao Kaiqiao acupuncture manipulation based on the treatment of the control group. Both groups were treated for two weeks. The changes in the levels of C-reactive protein(CRP)，interleukin- 6(IL-6)，interleukin- 8(IL-8)，tumor necrosis factor- α(TNF-α)，NBP and copeptin in serum before and after treatment as well as the clinical effect in the two groups were observed and compared；the adverse reactions were counted. Results：The total effective rate was 94.83% in the treatment group and 72.41% in the control group， the difference being significant(P＜0.05). After treatment， NIHSS scores in the two groups were significantly decreased when compared with those before treatment(P＜0.05)， and ADL scores were significantly increased(P＜0.05)；the improvement of the two indexes in the treatment group was obviously better than that in the control group(P＜0.05). After treatment，the levels of CRP，IL- 6，IL- 8，TNF- α，NBP and copeptin in serum in the two groups were all significantly decreased when compared with those before treatment(P＜0.05)，and the levels in the treatment group were lower than those in the control group(P＜0.05). The total incidence of adverse reactions was 3.45% in both the treatment group and the control group，and there was no significant difference(P＞0.05). Conclusion：The therapy of Xingnao Kaiqiao acupuncture manipulation combined with rat nerve growth factors for acute cerebral hemorrhage has significant clinical effect， and can effectively reduce the levels of serum inflammatory factors， NBP and copeptin， and thus improving the inflammatory responses of the body and the cerebral nerve function of patients.