Abstract： Objective： To study the mechanism of Radix Scutellariae in treating AIDS through network pharmacology. Methods：The chemical constituents and targets of Radix Scutellariae as well as the genes of AIDS were searched online to establish a protein interaction network. The biological process and signal pathway of Radix Scutellariae in treating AIDS were identified by GO function enrichment analysis and KEGG pathway enrichment analysis through online DAVID. Results：A total of 36 effective constituents and 110 targets of Radix Scutellariae were obtained，and they were mapped to 1，781 disease targets of AIDS，and then 48 mapped genes were obtained. Four key chemical constituents were obtained by constructing the protein interaction network， namely， acacia， baicalin， trihydroxyflavone and β- sitosterol， and three key targets， namely， Bax， Bcl2 and CASP8. GO function analysis showed that the gene functions of AIDS were mainly inflammatory response， cytoplasm and chromatin binding. By KEGG pathway enrichment analysis， tumor signaling pathway， p53 signaling pathway and PI3K-AKT signaling pathway were obtained. Conclusion：Through the analysis of network pharmacology， Radix Scutellariae may affect Bax，Bcl2，CASP8 targets of tumor signaling pathway，p53 signaling pathway and PI3K AKT signaling pathways through acacia ， baicalin ， trihydroxyflavone and β- sitosterol ， to regulate inflammatory response ， cytoplasm，and chromatin binding to treat AIDS.