冠心宁片治疗冠心病合并抑郁症临床研究
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R541.4

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Clinical Study on Guanxinning Tablets for Coronary Heart Disease Complicated with Depression
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    摘要:

    目的:观察冠心宁片治疗冠心病合并抑郁症的效果。方法:将冠心病合并抑郁症患者100 例随机分为对照组和观察组,每组50 例;对照组给予冠心病常规治疗方案进行治疗,观察组在对照组的基础上加用冠心宁片治疗,观察比较2 组治疗前后血清C-反应蛋白(CRP)、同型半胱氨酸(HCY) 水平,汉密尔顿抑郁量表(HAMD) 评分、抑郁自评量表(SDS) 评分、西雅图心绞痛量表(SAQ) 评分,评价2 组心电图临床疗效、抑郁症临床疗效及不良反应情况。结果:治疗后,2 组抑郁症临床疗效、心电图临床疗效比较,经秩和检验,差异圴有统计学意义(P<0.05),观察组疗效优于对照组。治疗后,2 组患者HAMD、SDS 评分均较治疗前降低(P<0.05),SAQ 评分较治疗前升高(P<0.05);且观察组上述各项评分改善均优于对照组(P<0.05)。治疗后,2 组血清CRP、HCY 水平均较治疗前降低(P<0.05);且观察组CRP、HCY 水平均低于对照组(P<0.05)。治疗过程中,2 组肝功能损伤、肾功能损伤、恶心、呕吐、皮疹、发热等不良反应率比较,差异均无统计学意义(P>0.05)。结论:冠心宁片治疗冠心病合并抑郁症,可有效改善患者心脏及抑郁症状,提高临床疗效,且安全性良好。

    Abstract:

    Abstract:Objective:To observe the curative effect of Guanxinning tablets for coronary heart disease complicated with depression. Methods: A total of 100 cases of patients with coronary heart disease complicated with depression were randomly divided into the control group and the observation group, 50 cases in each group. The control group was given routine treatment for coronary heart disease, and the observation group was additionally treated with Guanxinning tablets based on the treatment of the control group. Before and after treatment, the levels of C- reactive protein(CRP) and homocysteine(HCY) in serum as well as the scores of Hamilton Depression Scale(HAMD), Self- Rating Depression Scale (SDS) and Seattle Angina Questionnaire(SAQ) in the two groups were observed and compared. The clinical effect of electrocardiogram and depression as well as adverse reactions in the two groups were evaluated. Results:After treatment, the comparison of the clinical effect of electrocardiogram and depression showed significance in differences(P<0.05); the curative effect in the observation group was better than that in the control group. After treatment,the scores of HAMD and SDS in the two groups were decreased when compared with those before treatment(P<0.05), and the SAQ scores were increased(P<0.05);the improvement of the above scores in the observation group was better than that in the control group (P<0.05). After treatment, the levels of CRP and HCY in serum in the two groups were decreased when compared with those before treatment(P<0.05); the two levels in the observation group were lower than those in the control group(P< 0.05). During treatment,there was no significant difference being found in the comparison of incidence of adverse reactions including liver dysfunction, kidney dysfunction, nausea, vomiting, rash and fever between the twp groups(P>0.05). Conclusion:Guanxinning tablets in treating patients with coronary heart disease complicated with depression can effectively improve symptoms of heart and depression as well as clinical effect with good safety.

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黄晓城,江瑞来,李莉,华英,陈伟君.冠心宁片治疗冠心病合并抑郁症临床研究[J].新中医,2020,52(18):72-75

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  • 在线发布日期: 2020-09-20
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