Abstract： Objective： To observe the clinical effect of Yangwei granules combined with omeprazole enteric- coated capsules for patients with chronic atrophic gastritis and its influence. Methods：A total of 132 cases of patients with chronic atrophic gastritis were divided equally into the experiment group and the control group according to the random number table method，66 cases in each group. The control group was simply treated with omeprazole enteric-coated capsules，and the experiment group was additionally treated with Yangwei granules based on the treatment of the control group. The scores of the evaluation of gastroscopy and spleen- stomach weakness syndrome before and after treatment as well as the curative effect were compared and analyzed. Results： Before treatment， there was no significant difference being found in the comparison of the scores of the evaluation of gastroscopy and spleen-stomach weakness syndrome between the two groups (P＞0.05). After treatment， the above scores in the two groups were improved， and the improvement in the experiment group was better than that in the control group(P＜0.05). After treatment， the total effective rate was 96.97% in the experiment group and 87.88% in the control group， the difference being significant(P＜0.05). Conclusion： Compared with that of omeprazole enteric- coated capsules alone， the therapy of Yangwei granules combined with omeprazole entericcoated capsules has significant clinical effect in treating patients with chronic atrophic gastritis， and can improve their symptoms.