Abstract： Objective： To observe the effect of Qingre Jiedu therapy through oral administration of Chinese medicine combined with external fumigation on perianal abscess and wounds after surgery of anal fistula. Methods： A total of 100 cases of patients with perianal abscess and anal fistula were selected as the objects and randomly divided into two groups according to the computer number table method， 50 cases in each group. Both groups were treated with surgery. After surgery，the control group was given fumigation with potassium permanganate solution；the experiment group was given Qingre Jiedu therapy through oral administration of Chinese medicine combined with external fumigation. The quality of wound healing and the changes in scores of inflammatory factors， exudate and pain were compared between the two groups. Results：On the day after operation，when compared the levels of tumor necrosis factor-α(TNF-α)，interleukin-1β(IL- 1β) and interleukin- 8(IL- 8) in serum between the two groups， there was no significance in the difference(P＞0.05). After treatment，the levels of TNF- α，IL- 1β and IL- 8 in serum in the two groups were decreased，and the three levels in the experiment group were lower than those in the control group，the difference being significant(P＜0.05). After treatment，the time of wound healing and slough shedding in the experiment group were shorter than that in the control group；the degree of wound healing in the experiment group was higher than that in the control group；the score of granulation growth in the experiment group was lower than that in the control group， the difference being significant(P＜0.05). On the day after operation， when compared the scores of exudate and pain between the two groups， there was no significance in the difference(P＞0.05). After treatment，the scores of exudate and pain in the two groups were decreased；the two scores in the experiment group were lower than those in the control group，the difference being significant(P＜0.05). Conclusion：The therapy of Qingre Jiedu therapy through oral administration of Chinese medicine combined with external fumigation conduces to promoting wound healing after surgery of anal fistula in patients with perianal abscess，and improving the quality of wound healing.