Abstract：Objective：To observe the clinical effect of timing point application combined with intensive health education for chronic glomerulonephritis(CGN) and its effect on psychological state and sleep quality of patients. Methods：A total of 64 cases of CGN patients were divided in to the control group and the observation group according to their different treatment and nursing methods，32 cases in each group. The control group was given routine treatment and nursing； the observation group was additionally given timing point application combined with intensive health education based on the intervention of the control group，and the point application was applied in the three ten-day periods of the hot season and the three nine-day periods of the cold season. Before and after intervention，the 24-hour urinary protein in the two groups were compared. The clinical effect，psychological state and sleep quality in the two groups were evaluated and compared，and the incidences of adverse reactions in the two groups were observed. Results： After intervention， the 24- hour urinary protein in the two groups were decreased when compared with those before intervention(P＜0.05)，and the decrease in the observation group was more significant than that in the control group(P＜0.05). The total effective rate was 90.63% in the observation group， significantly higher than that of 62.50% in the control group(P＜0.05). After intervention， the scores of Self- Rating Depressing Scale(SDS)， Self- Rating Anxiety Scale(SAS) and Pittsburgh Sleep Quality Index(PSQI) in the two groups were decreased when compared with those before intervention(P＜0.05)， and the above scores in the observation group were lower than those in the control group(P＜0.05). During treatment，there was no severe adverse reaction in the two groups. Conclusion： Timing point application combined with intensive health education for CGN can effectively relieve clinical symptoms，and improve psychological state and sleep quality of patients with good safety.