Abstract： Objective： To summarize Prof. HE Yingchun's experience in the clinical medication and treatment in differentiating chronic fatigue syndrome. Methods：A total of 150 prescriptions were collected from 63 patients with chronic fatigue syndrome treated by Prof. HE. The characteristics of medication in those prescriptions were summarized by frequency distributionmethod，and his ideas of the treatment of the disease were discussed. Results：Prof. HE differentiated chronic fatigue syndrome into four types， namely spleen and stomach damp- heat type， liver depression and spleen deficiency type， qi- blood depletiontype， and kidney essence deficiency type， and treated them respectively with modified Sanren tang，Chaihu Shugan powder combined with Pingwei powder，Shiquan Dabu tang and Erxian tang. Among them，the top nine Chinese herbs used most frequently were Radix et Rhizoma Glycyrrhizae Praeparata cum Melle，Rhizoma Chuanxiong， fried Radix Paeoniae Alba， Poria， Radix Angelicae Sinensis， fried Fructus Aurantii， Pericarpium Citri Reticulatae， fried Rhizoma Atractylodis Macrocephalae and fried Fructus Setariae Germinatus. Conclusion： Guided by the principle of "reinforcing for the spleen and stomach and balancing yin and yang"，Prof. HE attaches great importance to strengthening the spleen and harmonizing the stomach as well as balancing yin and yang，and is good at using herbs combination and flexibly modifies them，resulting in significant therapeutic effect.