Objective：To observe the clinical effect of Guanmai Ningtong prescription combined with western medicine for angina pectoris.Methods：Selected 83 cases of patients with angina pectoris and divided them into the observation group with 43 cases and the control group with 40 cases according to the random number table.Both groups were treated with routine western medicine after admission.On this basis，the observation group was additionally given Guanmai Ningtong prescription and the control group was additionally given Chinese medicine placebo.Observed the clinical effect in the two groups after 12 weeks of continuous treatment.Results：The total effective rate in the observation group was 95.35%，being obviously higher than that of 70.00% in the control group(P＜ 0.05).Before treatment，there was no significant difference being found in the comparison of the levels of serum transforming growth factor- β1(TGF- β1)，interleukin-6(IL-6)，tumor necrosis factor-α(TNF-α)and high-sensitivity C-reactive protein(hs-CRP)in the two groups(P ＞ 0.05).After treatment，the levels of serum TGF-β1，IL-6，TNF-α and hs-CRP in the two groups were decreased when compared with those before treatment and the levels of serum TGF-β1，IL-6，TNF-α and hs-CRP in the observation group were lower than those in the control group，differences being significant(P ＜ 0.05).Before treatment，there was no significant difference being found in the comparison of Chinese medicine syndrome scores in the two groups(P＞ 0.05).After treatment，the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment and the Chinese medicine syndrome scores in the observation group were lower than those in the control group，differences being significant(P＜0.05).Before treatment， there was no significant difference being found in the comparison of the average plaque thickness，average quantity of plaque and average plaque area in the two groups(P＞ 0.05).After treatment，the average plaque thickness，average quantity of plaque and average plaque area in the two groups were decreased when compared with those before treatment and the average plaque thickness，average quantity of plaque and average plaque area in the observation group were lower than those in the control group，differences being significant(P＜ 0.05).Conclusion：The application of Guanmai Ningtong prescription combined with western medicine for angina pectoris can effectively inhibit the inflammatory reactions and improve the morphology and clinical symptoms of coronary plaque，which has evident clinical effect and is worthy of promotion and application.