Objective：To observe and analyze the clinical effect of Naoxintong capsules and routine western medicine combined with isokinetic exercise for hemiplegia after stroke.Methods：A total of 200 cases of patients with hemiplegia after stroke were divided into the study group and the control group according to the odd-even number grouping method，100 cases in each group.Both groups were treated with clinical isokinetic exercise；the control group was additionally treated with tizanidine，and the study group was additionally treated with Naoxintong capsules based on the treatment of the control group.After treatment for four weeks， the clinical effect in the two groups was observed.Results： Before treatment，compared with the levels of fibrinogen(FIB)， prothrombin time(PT)， thrombin time(TT)and activated partial thromboplastin time(APTT)，there was no significance in the difference(P ＞ 0.05).After treatment，the levels of FIB，PT，TT and APTT in the two groups were increased when compared with those before treatment，and the improvement of the above levels in the study group was larger than that in the control group(P＜ 0.05).Before treatment，compared with the scores of short-form Fugl-Meyer Assessment(FMA)and Modified Barthel Index(MBI)in the two groups，there was no significance in the difference(P＞ 0.05).After treatment，the scores of FMA and MBI in the two groups were increased when compared with those before treatment，and the improvement of the above two scores in the study group was larger than that in the control group(P＜ 0.05).After treatment，the total effective rate was 89.00% in the study group and 66.00% in the control group，the difference being significant(P＜0.05).Conclusion：The therapy of Naoxintong capsules and routine western medicine combined with isokinetic exercise has exact curative effect in treating patients with hemiplegia after stroke，which can effectively improve their coagulation function and activities of daily living，and recover their extremity motor function.