Objective：To observe the clinical effect of precompounded Lijin Jianyao prescription combined with epidural block for lumbar disc herniation(LDH).Methods：A total of 88 cases of LDH patients were selected as the study subjects，and were divided into the control group and the observation group according to the random number table method，44 cases in each group.The control group was treated with epidural block，and the observation group was additionally treated with precompounded Lijin Jianyao prescription based on the treatment of the control group.Both groups were treated for two weeks.The excellent and good rate of the lumbar function in the two groups after treatment were compared；lumbar function，sense of pain and activity of daily living before and after treatment were evaluated；the levels of β-endorphin(β-EP)， substance P(SP)， monocyte chemotactic protein 1(MCP-1)and prostaglandin E2(PGE2)in serum before and after treatment were detected.Results：The excellent and good rate was 70.45% in the observation group and 38.64% in the control group，the difference being significant(P ＜ 0.05).After treatment，the scores of Japanese Orthopaedic Association(JOA)in the two groups were increased when compared with those before treatment，and the scores of Visual Analogue Scale(VAS)and Oswestry Disability Index(ODI)were decreased when compared with those before treatment(P ＜ 0.05)；the score of JOA in the observation group was higher than that in the control group，and the scores of VAS and ODI were lower than those in the control group respectively(P ＜ 0.05).After treatment，the levels of β-EP in the two groups were increased when compared with those before treatment(P ＜ 0.05)，and the levels of SP，MCP-1 and PGE2 were decreased when compared with those before treatment(P ＜ 0.05)；the level of β-EP in the observation group was higher than that in the control group(P＜0.05)，and the levels of SP，MCP-1 and PGE2 were lower than those in the control group respectively(P＜0.05).Conclusion：The therapy of precompounded Lijin Jianyao prescription combined with epidural block in treating LDH is beneficial to improving clinical symptoms as well as lumbar function，and relieving pain，whose mechanism may be related to the regulation of the levels of cytokines including β-EP，SP，MCP-1 and PGE2 in serum.