Objective：To observe the therapeutic effect of the therapy of Semen Arecae And Radix Aucklandiae Powder at CV8 combined with montmorillonite powder on azithromycin-induced gastrointestinal reactions.Methods：A total of 163 patients intravenously dripped with azithromycin were divided into the control group(64 cases)and the observation group(99 cases)according to different preventive and treating methods.Both groups were given montmorillonite powder with warm water 30 minutes before intravenous drip of azithromycin；in the observation group，the ointment made of Semen Arecae And Radix Aucklandiae powder was applied toshenquepoint(CV8)30 minutes before intravenous drip of azithromycin and lasted until two hours after its finish.Both groups were observed continuously for seven days.The number of cases，occurrence time and duration time of gastrointestinal reactions including nausea，vomiting，abdominal pain and diarrhea were recorded，and the degree of symptoms of gastrointestinal reactions were evaluated.Results：After treatment，the incidence of gastrointestinal reactions was 8.08% in the observation group，lower than that of 23.44% in the control group(P＜0.01).The degree of gastrointestinal reactions in the observation group was less than that in the control group(P＜0.05).There was no significant difference being found in the comparison of occurrence time of gastrointestinal reactions between the two groups(P＞ 0.05).The duration time of nausea，vomiting，abdominal pain and diarrhea in the observation group was shorter than that in the control group(P＜ 0.05).Conclusion：For patients intravenously dripped with azithromycin，the therapy of Semen Arecae And Radix Aucklandiae Powder at CV8 combined with montmorillonite powder，can reduce the incidence of azithromycin-induced gastrointestinal adverse reactions，decrease the degree of adverse reactions and promote theelimination of gastrointestinal symptoms.